Relationship Between MRS NAA Concentration and DTI ADC Values

Nuran Tunc-Skarka¹, Wolfgang Weber-Fahr¹, Mareen Hoerst¹, Gabriele Ende¹

Diffusion tensor imaging and proton magnetic resonance spectroscopy (MRS) yield different parameters for characterizing the evolution of a demyelinazation in white matter disease. NAA is commonly believed to provide a marker of neuronal density. Diffusion tensor imaging may give information about the axonal impairment of the neurons by changes of the patterns of anisotropy, e.g. fractional anisotropy (FA) or apparent diffusion coefficient (ADC). In this we study estimated and compared FA and ADC within a spectroscopic single voxel evaluate a possible direct relationship between those different measurement methods of similar objective of investigation.