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Abstract #2375

Tailoring Linear Response Equilibrium Spectroscopy of Cholesterol Esters

Rudolf Fritz Fischer1, Sebastian Kozerke1, Christof Baltes1, Markus Rudin1, Peter Boesiger1

1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland

The Linear Response Equilibrium Sequence (LRE) can be used as a time and energy efficient MR sequence for 1H-spectroscopy. In this study, we tailor the LRE sequence for cholesterol ester detection. Sequence intrinsic aliasing of sidebands can be suppressed by a change in the pulse pattern exciting a dual steady-state. In addition, a frequency selective water suppression module has been introduced into the LRE sequence. Measurements performed on a phantom filled with liquid cholesterol linoleate proved the performance of the new sequence elements.