Abstract #2383

High-Resolution NMR Spectra of Heterogeneous Biological Tissues Via Intermolecular Single-Quantum Coherences

Yuqing Huang¹, Zhong Chen^1,2, Shuhui Cai¹, Jianhui Zhong²

¹Physics Department, Xiamen University, Xiamen, Fujian, China; ²Radiology and Biomedical Engineering, University of Rochester, Rochester, NY, USA

In in vivo NMR study, inhomogeneous line broadening due to magnetic susceptibility gradients and intensive water signal often leads to severe spectral peak overlapping and weak signal obstructing. In this abstract, a new pulse sequence based on intermolecular single-quantum coherences (iSQC) was presented for high-resolution spectra from biological tissues. Several heterogeneous biological samples were measured to test the feasibility of the pulse sequence. The experimental results indicate that the method is a useful tool of high-resolution MRS for heterogeneous biological samples.