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Abstract #2384

Multiple Spin Echo Spectroscopic Imaging of Glutamate and Glutamine (Glx)

Atiyah Yahya1,2, B. Gino Fallone1,2

1Department of Medical Physics, Cross Cancer Institute, Edmonton, Alberta, Canada; 2Department of Oncology, University of Alberta, Edmonton, Alberta, Canada

Collective levels of glutamate and glutamine (Glx) are of value in the study of many diseases. In-vivo levels of Glx can be assessed by spectroscopic imaging. The turbo spectroscopic imaging (TSI) technique has shown to be useful for the fast acquisition of signal from non-coupled protons from multiple slices. TSI is not applicable to coupled spins because the J-modulation as a function of time can cause spatial misregistrations. In this work, a TSI sequence is presented that can yield high signal, from the C2 protons of Glx. The efficacy of the sequence was verified on phantoms and on brain.