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Abstract #2393

A Systematic Approach for Chemical Quantification in MRSI: Methodological Considerations

Neva M. Corrigan1, Todd L. Richards1, Helen Petropoulos1, Seth D. Friedman2, Stephen R. Dager1

1Radiology, University of Washington, Seattle, WA, USA; 2Radiology, Children's Hospital and Regional Medical Center/University of Washington, Seattle, WA, USA

Magnetic resonance spectroscopic imaging (MRSI) allows for a tremendous volume of data to be produced in a single scan. These data sets, however, can be very cumbersome to process. In this work we evaluate a proposed systematic approach for chemical quantification in MRSI data sets that is capable of making use of the information contained in the data set to increase regional specificity was well as increase the reliability of the calculated chemical concentrations. We demonstrate the benefits of this method by applying it to quantification of lactate during sodium lactate infusion in healthy adults.