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Abstract #2394

Optimized Detection of Glutamate and Glutamine at 1.5 T, 3 T and 4.7 T

Jeff Snyder1,2, Richard B. Thompson3, Alan H. Wilman2,3

1Dept. of Diagnostic Radiology, Medical Physics, University Hospital Freiburg, Freiburg, Germany; 2Physics, University of Alberta, Edmonton, Alberta, Canada; 3Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada

The detection of glutamate and glutamine independently via PRESS magnetic resonance spectroscopy is highly dependent on the chosen field strength and echo time parameters. In this study, optimized timing simulations were performed at three field strengths (1.5 T, 3 T and 4.7 T) to minimize the overlap of glutamate and glutamine in the 2.0 2.7 ppm range and provide better discrimination. The results of the optimization are applied in vivo at 1.5 T and 4.7 T in the human brain. The best result occurs at 4.7 T, with a maximum calculated overlap of 4%.