Quantitative 2D In-Vivo Spectroscopy Using the ERETIC Method

Alexander Fuchs¹, Susanne Heinzer-Schweizer¹, Anke Henning¹, Peter Boesiger¹

A fundamental requirement to use spectroscopy in a clinical setting is the ability to reliably quantify the individual metabolites. While 2D experiments like JPRESS can provide improved spectral separation by dispersing spectral information in an additional frequency dimension the artificially injected ERETIC signal can serve as a stable and well known reference signal. It is shown that the ERETIC reference signal can be readily incorporated into in-vivo 2D spectroscopic experiments, which finally provides the necessary premises for reliable quantification in in-vivo 2D MRS.