Alexander Fuchs1, Anke Henning1, Thomas Lange2, Peter Boesiger1
1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland; 2Dept. of Diagnostic Radiology, Medical Physics University Hospital Freiburg, Freiburg, Germany
2D spectroscopy offers the advantage of increased spectral resolution and therefore increases the possibility of fitting even strongly overlapped signals like Glu, Gln or GABA independently. The signals of 18 metabolites were simulated for typical in vivo line widths and spectral separation at 3T. Subsequently the correlations obtained from the Fisher information matrices were compared between a standard singel voxel PRESS, 2D L-COSY and a maximum echo sampled JRPESS sequence. The results clearly show how the correlations decrease and as a consequence the orthongonality of the basis set for the 2D spectroscopic experiments is drastically improved.
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