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Abstract #2410

Hyperpolarized 13C 3D Metabolic Imaging with Stimulated Echoes for Flow Suppression

Peder E. Z. Larson1, Ralph Hurd2, Adam B. Kerr3, Robert Bok1, John Kurhanewicz1, Daniel B. Vigneron1

1Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, CA, USA; 2Global Applied Science Lab, GE Healthcare, Menlo Park, CA, USA; 3Electrical Engineering, Stanford University, Stanford, CA, USA

We have developed and applied a novel stimulated echo sequence for hyperpolarized 13C metabolic imaging. The stimulated echo encoding is used with injected [1-13C]-pyruvate to suppress metabolites that are flowing by including a mixing time (1 s) between the encoding and acquisition. Only stationary spins are refocused, thus providing unique information about the mobility of the metabolites. In a mouse prostate cancer model, this method increased the discrimination between tumor and normal tissues based on 13C-lactate detection, highlighting the differences in metabolite flow.