Abstract #2411

Improved Resolution of 2D and 3D [1-13C] Hyperpolarized MRSI Using a 3-Element Coil and SENSE Reconstruction

Janine M. Lupo¹, Peder E. Larson¹, Albert P. Chen², James Tropp³, Esin Ozturk-Isik¹, Daniel B. Vigneron¹, Ralph Hurd³, Sarah J. Nelson¹

¹Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA; ²Global Applied Science Lab, GE Healthcare, Toronto, Canada; ³Global Applied Science Lab, GE Healthcare, CA, USA

This study implemented a SENSE acquisition and reconstruction to increase the spatial resolution of ¹³C MRSI of rats at 3T using a custom-built 3-element receive coil. ¹³C MRSI data were acquired using a 2D standard phase encoding and 3D phase encoding with flyback spatial trajectories. The 3D flyback ¹³C MRSI with SENSE allowed for full coverage of a rat body in 16s with a 0.5cc spatial resolution. This technique did not significantly compromise the overall spectral quality of the spectra, resulting in higher SNR than theoretically expected based on the g-factors for labeled pyruvate, lactate, and alanine in most anatomical regions.