John Dewolfe MacKenzie1, Dirk Mayer1, Yi-Fen Yen2, Shreyas Vasanawala1, James Tropp2, Daniel M. Spielman1
1Radiology, Stanford University, Stanford, CA, USA; 2Global Applied Science Laboratory, GE Healthcare, Menlo Park, CA, USA
This preliminary study suggests that pyruvate metabolism may serve as a biomarker of arthritis activity. This study also suggests that arthritis activity may be visualized and quantified with hyperpolarized 13C-1-pyruvate MR spectroscopy.