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Abstract #2415

Hyperpolarized 13C MRS in the Rat Brain: Spectral Improvements with 1H Decoupling

Malgorzata Marjanska1, Dinesh K. Deelchand1, Isabelle Iltis1, Pierre-Gilles Henry1

1Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, MN, USA

Most in vivo studies using the dynamic nuclear polarization technique to enhance sensitivity of 13C have been utilizing molecules with 13C labeled quaternary carbons. These carbons possess small long-range J-couplings with protons. Here we show that, although 1H-decoupling has little impact on the [1-13C]pyruvate resonance it significantly improves the linewidth and SNR of [1-13C]lactate, [2-13C]pyruvate and [2-13C]lactate.