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Abstract #2417

Probing the In Vivo Compartmentalization of Hyperpolarized Pyruvate Using Gadodiamide Induced T1 Relaxation

Eric T. Peterson1, Jeremy W. Gordon2, Krishna N. Kurpad2, Sean B. Fain2, Ian J. Rowland3

1Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, USA; 2Medical Physics, University of Wisconsin - Madison, Madison, WI, USA; 3Radiology, University of Wisconsin - Madison, Madison, WI, USA

The biodistribution of hyperpolarized metabolites is of great importance in hyperpolarized 13C experiments. Spectral imaging can determine the spatial locations of the metabolites; however, the different biological compartments may reside within a single voxel. This work probes the intra and extra cellular compartmentalization of hyperpolarized molecules by using Gadodiamide induced T1 relaxation to increase the relaxation time of the extra cellular components. By quantifying the T1 relaxation before and after Gadodiamide injection, the intra cellular, extra cellular, and intra vascular components of each spectral component may be determined.