Abstract #2440

Validation of an Efficient and Compact Para-Hydrogen Catalytic Converter System for PHIP Studies

Ayelet Gamliel^1,2, Hyla Allouche-Arnon^1,3, Ruppen Nalbandian^1,3, Elena Vinogradov⁴, Aaron K. Grant⁴, Robert E. Lenkinski⁴, Claudia M. Barzilay², J. M. Gomori¹, Rachel Katz-Brull¹

¹Department of Radiology, Hadassah Hebrew University Medical Center, Jerusalem, Israel; ²Medicinal Chemistry, School of Pharmacy , The Hebrew University of Jerusalem, Jerusalem, Israel; ³Department of Physiology, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel; ⁴Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

An efficient and compact para-hydrogen catalytic converter system for PHIP studies is described. The system consists of local production of small predetermined amounts of hydrogen and an efficient and convenient catalytic converter at ambient pressure. In this system, the enhancement factor per concentration was c.a. 2,100 and c.a.3,500 for 1H- and 13C- ALTADENA studies, respectively. The system proved to be an excellent source of para-hydrogen for PHIP studies in a hospital/MRI suite environment.