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Abstract #2503

In Vivo MR Elastography of Liver: Comparison to Oscillatory Rheometer Studies of Tissue Specimen

Dieter Klatt1, Christian Friedrich2, Asbach Patrick1, Hasan Nuzha1, Katrin Rettig1, Sebastian Papazoglou1, Uwe Hamhaber3, Juergen Braun3, Ingolf Sack1

1Dept. of Radiology, Charite - University Medicine, Berlin, Germany; 2Materials Research Center, University of Freiburg, Germany; 3Inst. of Medical Informatics, Charite - University Medicine, Berlin, Germany

MR elastography enables the measurement of the complex shear modulus of living soft tissue at multiple driving frequencies. The resulting dispersion function indicates microstructural tissue properties which significantly change through disease. In this study, bovine liver specimens were investigated by oscillatory rheometry. Below 50 Hz driving frequency, the observed modulus dispersion followed a powerlaw in good approximation. This observation agrees to in vivo multifrequency MRE data of healthy human liver suggesting the use of the two-parameter springpot model in liver MRE.