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Abstract #2523

Image-Guided Modulation of Regional Brain Function Mediated by Focused Ultrasound

Seung-Schik Yoo1, Alexander Bystritsky1,2, Jong-Hwan Lee1, YongZhi Zhang1, Krisztina Fischer1, Wonhye Lee1, Nathan McDannold1, Ferenc A. Jolesz1

1Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; 2Psychiatry, UCLA, Los Angeles, CA, USA

Utilizing the minimally-invasive nature of the Focused ultrasound (FUS), selective modulation of regional neural activity in brain was sought after, and we found early evidence that FUS, as administered in train of pulses (i.e. focused ultrasound pulse: FUP), mediated reversible modulation of cortical activity in animal model.