Abstract #2524

First Human Application of Laser Interstitial Thermal Therapy in GBM Using MR Guided AutoLITT System

Stephen Jones¹, Gene Barnett², Jeffrey L. Sunshine³, Mark Griswold³, Andrew Sloan⁴, Micheal D. Phillips⁵, Richard Tyc⁶, Mark Torchia⁷

¹Imaging Institute, Cleveland Clinic, Cleveland, OH, USA; ²Neurological Institute, Cleveland Clinic, Cleveland, OH, USA; ³Department of Radiology, University Hospitals Case Medical Center, Cleveland, OH; ⁴Department of Neurosurgery, University Hospitals Case Medical Center, Cleveland, OH; ⁵Imaging Institute, Cleveland Clinic, Cleveland , OH, USA; ⁶Monteris Medical Inc, Winnipeg, Manitoba, Canada; ⁷Department of surgery, University of Manitoba, Winnipeg, Manitoba, Canada

Glioblastoma (GB) is the most frequent primary brain malignancy in adults, usually resulting in death in 1-2 years despite decades of research. Although treatments such as surgery, chemotherapy, and radiation extend survival several months, recurrence is inevitable making minimally invasive therapies attractive. We describe the first human application of laser interstitial thermal therapy (LITT) of a GBM using the Monteris AutoLITT system. This system is unique in using real-time MRI thermometry to contour treatment precisely within the confines of the tumor. The AutoLITT produced thermal lesion appeared to stabilize after 48 hours and was accurately predicted by the AutoLITT software.