Abstract #2558

Transcatheter Intraarterial Perfusion (TRIP)-MRI Monitoring of Uterine Fibroid Embolization in VX2 Rabbits

Dingxin Wang¹, Robert Ryu², Johnathan Chung², Richard Tang², Rachel Klein², Barbara Szolc-Kowalska³, Gayle Woloschak^3,4, Reed Omary^1,4, Andrew Larson^1,4

¹Departments of Radiology and Biomedical Engineering, Northwestern University, Chicago, IL, USA; ²Department of Radiology, Northwestern University, Chicago, IL, USA; ³Radiation Oncology, Northwestern University, Chicago, IL, USA; ⁴Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA

Proper selection of UAE endpoints is critical because under-embolization may cause incomplete treatment and over-embolization may harm normal uterine tissue and generate excessive post-procedural ischemic pain. TRanscatheter Intraarterial Perfusion (TRIP)-MRI (involving catheter-directed intraarterial contrast injections) has been demonstrated to permit intra-procedural measurement of tumor perfusion changes during liver-directed embolo-therapies. As a step towards determining the optimal endpoint for UAE, we tested the hypothesis that TRIP-MRI can measure uterine fibroid perfusion reductions during UAE in a rabbit VX2 uterine tumor model. TRIP-MRI can be used to objectively measure uterine fibroid perfusion reduction after UAE in a rabbit uterine tumor model.