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Abstract #2559

Diffusion-Weighted PROPELLER MRI for Tissue Selective Intra-Procedural Positioning of Percutaneous Biopsy Needles Within Rabbit VX2 Liver Tumors

Jie Deng1,2, Sumeet Virmani1, Richard A. Tang1, Guang-Yu Yang3, Gayle Woloschak1,4, Reed A. Omary1,5, Andrew C. Larson1,5

1Department of Radiology, Northwestern University, Chicago, IL, USA; 2Department of Medical Imaging, Children's Memorial Hospital, Chicago, IL, USA; 3Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; 4Department of Cell and Molecular Biology, Northwestern University, Chicago, IL, USA; 5Robert H. Lurie Comprehensive Cancer Center , Northwestern University, Chicago, IL, USA

MRI can be used for intra-procedural guidance during percutaneous liver-directed interventions. Optimal targeting of viable tumor tissues is critical during biopsy procedures for accurate histological confirmation of malignancy. Diffusion-weighted (DW) MRI can be employed for in vivo differentiation between viable tumor tissues and tumor. TSE-based DW-PROPELLER techniques should be less sensitive to susceptibility-induced field inhomogeneities near interventional devices. We demonstrated the feasibility of using DW-PROPELLER MRI to guide biopsy needle placement to selectively target viable tissues within VX2 rabbit liver tumors. DW-PROPELLER is a promising method to optimize placement of percutaneous devices during interventional procedures.