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Abstract #2754

Positive Iron Contrast by Flow Enhanced Off-Resonance-Saturation for Remote Detection of Iron Based Contrast Agents

Philipp Krmer1, Xavier Helluy1, Esra Lang1, Peter Michael Jakob1

1Department of Experimental Physics V, University of Wrzburg, Wrzburg, Bavaria, Germany

Hypointense contrast originating from iron-loaded atherosclerotic plaques within a vessel wall have been observed in contrast-enhanced gradient echo based MRA images of vessel lumen, allowing a fast remote detection of iron-loaded plaques. We demonstrate here on a flow phantom how a more specific positive iron contrast mechanism - flow enhanced off-resonance saturation (feORS) -, combined with MRA might facilitate the detection of iron based contrast agents confined within a small vessel wall volume.