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Abstract #2755

Switching of MRI Contrast Agents with Ultrasound

Nouri Elmiladi1, Christian Hoehl1, Karl Maier1

1Helmholtz-Institut fr Strahlen- und Kernphysik (HISKP), Rheinische Friedrich-Wilhelms-Universitt, Bonn, Germany

A method involving the application of ultrasound (US) while performing proton nuclear magnetic resonance (1HNMR) spectroscopy in the presence of antibody coated magnetic nanoparticles has been developed. Especially prepared magnetic nanoparticles act as an US driven radio frequency antenna, emitting photons of US frequency. Influence of resonant US on 1HNMR using the asymmetric magnetic nanoparticles is examined through the determination of the relaxation rate by an inversion recovery sequence. Measurements are obtained for two different sizes of magnetic particles. A significant increase of the relaxation rate is observed when using smaller sized particles.