Osamu Abe1, Hidemasa Takao1, Hiroyuki Kabasawa2, Hidenori Yamasue3, Masami Goto4, Wataru Gonoi1, Harushi Mori1, Akira Kunimatsu1, Yoshitaka Masutani1, Kiyoto Kasai3, Kuni Ohtomo1
1Department of Radiology, University of Tokyo, Tokyo, Japan; 2GE Yokogawa Medical Systems, Tokyo, Japan; 3Department of Neuropsychiatry, University of Tokyo, Tokyo, Japan; 4Radiological Technology, University of Tokyo Hospital, Tokyo, Japan
We investigate the effects of distortion and inhomogeneity correction on brain morphometry with 3T MRI. Significant group difference was observed in the brainstem, bilateral cerebral and cerebellar cortices between uncorrected and corrected images using SPM5 and FreeSurfer. Gradient-nonlinearity-induced spatial distortion and signal inhomogeneity correction allow accurate cross-platform or longitudinal comparisons of quantitative morphometry results.