Abstract #2915

Effects of Distortion and Inhomogeneity Correction on Brain Morphometry with 3T MRI

Osamu Abe¹, Hidemasa Takao¹, Hiroyuki Kabasawa², Hidenori Yamasue³, Masami Goto⁴, Wataru Gonoi¹, Harushi Mori¹, Akira Kunimatsu¹, Yoshitaka Masutani¹, Kiyoto Kasai³, Kuni Ohtomo¹

¹Department of Radiology, University of Tokyo, Tokyo, Japan; ²GE Yokogawa Medical Systems, Tokyo, Japan; ³Department of Neuropsychiatry, University of Tokyo, Tokyo, Japan; ⁴Radiological Technology, University of Tokyo Hospital, Tokyo, Japan

We investigate the effects of distortion and inhomogeneity correction on brain morphometry with 3T MRI. Significant group difference was observed in the brainstem, bilateral cerebral and cerebellar cortices between uncorrected and corrected images using SPM5 and FreeSurfer. Gradient-nonlinearity-induced spatial distortion and signal inhomogeneity correction allow accurate cross-platform or longitudinal comparisons of quantitative morphometry results.