Abstract #3113

The Effect of Longitudinal Magnetic Resonance Imaging on the Quality of Neurophysiological Recordings Using Implanted Micro-Wire Electrodes.

Kunal Paralikar¹, Thomas Neuberger², Joy Matsui¹, Alistair Barber³, Ryan Clement¹, Andrew Webb^1,4

¹Bioengineering, Penn State University, University Park, PA, USA; ²Huck Institute, Penn State University, USA; ³Opthalmology, Penn State University; ⁴Radiology, Leiden University Medical Center, Leiden, Netherlands

The purpose of this paper was to investigate: (1) the feasibility of carrying out longitudinal MRI studies in animals with implanted micro-wire electrodes adapted for MRI compatibility, (2) the effect of MRI studies on the quality of neurophysiological recordings, and (3) the use of MRI to study the extent and recovery of tissue damage due to electrode insertion. There was no evidence of short-term or chronic neural damage caused by repeated MRI, nor any statistical difference in the quality of the electrophysiological recordings between animals that had undergone MRI scans and those that had not.