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Abstract #3115

In Vivo Targeting of α ν β 3-Specific Dual-Modality Micellar Nanoprobes

Chase W. Kessinger1, Osamu Togao1, Chalermchai Khemtong1, Masaya Takahashi1, Jinming Gao1

1UT Southwestern Medical Center, Dallas, TX, USA

Here we report an α vb3-specific dual-imaging magnetofluorescent nanoprobes that allowed detection of angiogenic tumor vessels by both fluorescent and magnetic resonance imaging. The α vb 3-targeting specificity and temporal tumor accumulation profiles were demonstrated in a human lung tumor xenograft model in nude mice in vivo.