A Boron/Gd/LDL Adduct for Imaging-Guided Neutron Capture Therapy

Simonetta Geninatti¹, Diego Alberti, Antonio Coppino², Ibolya Szabo², Annamaria Deagostino³, Paolo Venturello², Silvio Aime²

LDLs act as efficient carriers for the delivery of a new imaging probe containing Gd and Boron. It follows that imaging guided Boron Neutron Capture Therapy appears possible as, from the signal enhancement generated by the paramagnetic Gd(III) complexes, we access to the key information that the 10B concentration threshold has been reached.