Abstract #3117

Gd(III)-Based Probes for MR Imaging of Exofacial Protein Thiols

Giuseppe Digilio¹, Valeria Menchise², Valeria Catanzaro³, Franco Fedeli³, Roberta Napolitano³, Concetta Gringeri¹, Eliana Gianolio³, Silvio Aime³

¹DISAV, University of Eastern Piedmont, Alessandria, AL, Italy; ²IBB, CNR, Italy; ³Chemistry IFM, University of Torino, Italy

A new Gd(III)-based contrast agent (CA) targeting the exofacial protein thiols is presented. Uptake experiments with cultured K562 cells show that the CA is efficiently bound to surface protein thiols and at least partially internalized. The amount of uptaken Gd(III) per cell is well above the threshold for visualization by MRI.