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Abstract #3127

High T1-Relaxivity Nanoparticles for Target Labeling of Ovarian Cancer

Sergey Magnitsky1, Anatoliy V. Popov1, Chunsheng Li2, Jennifer Swails2, Stephen Pickup1, George Coukos2, Jerry D. Glickson1

1Radiology, The University of Pennsylvania, Philadelphia, PA, USA; 2Department of Obstetrics and Gynecology, The University of Pennsylvania, Philadelphia, PA, USA

We developed a method for synthesizing targeted nanoparticles with high longitudinal relaxivity for MRI detection of ovarian cancer. We have incorporated Gd-DTPA-DSA and scFv-fragments of tumor specific antibodies into lipid shells of 200 nm diameter perfluorocarbon nanoparticles. The particles exhibit a longitudinal relaxivity of 28.2 mmol-1sec-1 at 18C, 9.4 T per Gd and a high affinity for human ovarian cancer cells. These studies demonstrate the potential application of these contrast agents for in vivo application.