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Abstract #3128

Development of Spontaneously Disassembling Dendrimers as a Platform Technology for PARACEST MRI Contrast Agents

Yuguo Li1, Mark D. Pagel1

1Arizona Cancer Center, University of Arizona, Tucson, AZ, USA

Spontaneously disassembling dendrimers are nanocarriers can carry high payloads of chemotherapies to pathological tissues, and then rapidly release the chemotherapies during enzyme-triggered spontaneous disassembly of the dendrimers. To investigate whether a spontaneously disassembling systems can generate a PARACEST effect, a non-dendritic model system was shown to generate a PARACEST effect after enzyme-triggered spontaneous disassembly. To investigate the translation of this approach to a dendritic system, the G0 core of a spontaneously disassembling dendrimer was designed and synthesized. This platform technology is being refined for PARACEST MRI.