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Abstract #3217

Accurate Estimation of Tissue Volumes by Means of Quantitative MR on Patients with Multiple Sclerosis

Janne West1,2, Jan B. Warntjes2,3, Peter Lundberg1,2, Anne Marie Landtblom4

1Department of Medicine and Health, Division of Radiation Physics, Linkping, Sweden; 2Center for Medical Imaging Science and Visualization, Linkping, Sweden; 3Department of Medicine and Health, Division of Clinical Physiology, Linkping, Sweden; 4Department of Clinical and Experimental Medicine, Division of Neurology, Linkping, Sweden

Using quantitative MRI the tissue specific parameters R1, R2 and PD (R1=1/T1, R2=1/T2) are quantified. It is shown that volume fraction of tissues in a voxel can be related to R1, R2 and PD measurements. Using this method it is possible to accurately calculate tissue volumes on a sub-voxel scale. This method were used in a group of patients with Clinically Definite Multiple Sclerosis (CDMS) to asses tissue volumes of white matter (WM), gray matter (GM), cerebrospinal fluid (CSF) and MS plaque for whole brain coverage.