Abstract #3218

Hydration Status Does Not Affect Brain Water Content or Myelin Water Fraction in Healthy Volunteers

Irene Margaret Vavasour¹, Cornelia Laule¹, Shannon H. Kolind², Roger Tam¹, Jimmy Lee³, Burkhard Maedler⁴, Anthony L. Traboulsee³, David K. Li¹, Alex L. MacKay^1,2

¹Radiology, University of British Columbia, Vancouver, British Columbia, Canada; ²Physics and Astronomy, University of British Columbia, Vancouver, British Columbia, Canada; ³Medicine, University of British Columbia, Vancouver, British Columbia, Canada; ⁴Phillips Healthcare, Vancouver, British Columbia, Canada

As the magnetic resonance signal is primarily from water, a persons hydration status could potentially influence the values of MR parameters from brain. In this study, histograms of water content, myelin water fraction, T₁ and T₂ were obtained from brain in 20 healthy volunteers in four acquisitions: before and after drinking 3 litres of water and two scans after fasting for 9 hours. No significant differences were found between the MR parameter histograms from the four sessions, indicating that brain hydration was affected minimally by the protocol.