Jieun Kim1, Sang-Pil Lee1,2, Mary L. Michaelis3, In-Young Choi1,4
1Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, USA; 2Department of Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA; 3Department of Pharmacology and Toxocology, University of Kansas, Lawrence, KS, USA; 4Department of Neurology, Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA
Triple transgenic AD (3xTg-AD) mice model progressively develops both Ab plaques and neurofibrillary tangle pathology with accompanying neuronal death in brain regions similar to those seen in human AD. In vivo 1H MRS can provide information of neurochemical alterations in the living brain. In this study, an ultra-short echo time 1H MRS was employed to detect development of AD pathology of 3xTg-AD mice over time. Our results showed that alterations in neurochemicals such as NAA, glutamine and lactate were not pronounced at 2 months of age except taurine, but starts to be rather extensive as early as 3 months of age. The neurochemical profiles obtained by 1H MRS would provide an insight to the neurological effect in AD pathology.
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