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Abstract #3308

Aluminum Mediated Changes in Rat Brain Using MRI/ MTC Imaging

Deepa Prajapati1, Sanjay Annarao1, Sandeep Tripathi2, Abbas Ali Mahdi2, Farzana Mahdi3, Mahdi Hasan4, Raja Roy1, C L. Khetrapal1

1CBMR, Centre of Biomedical Magnetic Resonance, LUCKNOW, U.P., India; 2Biochemistry, Chattrapati Shahuji Maharaj Medical University, LUCKNOW, U.P., India; 3Biochemistry, Eras Lucknow Medical College and Hospital, LUCKNOW, U.P., India; 4Anotomy, Chattrapati Shahuji Maharaj Medical University, LUCKNOW, U.P., India

Aluminum induced alterations in rat brain have been studied by MRI using MT effect in rats administering Al3+ in three different ways i.e. Al3+ alone, Al3+with Bacoside, Al3+with Donepezil and the results were compared with positive control. MTR has been evaluated successively for three months. Statistically, significant differences were observed in MTR of second and third month in Al3+ treated group and in MTR of Al3+ and B treated group during third month. The results indicate Al3+ overload has implications similar to AD. The effect of Donepezil and Bacoside is indicative of their different mode of action in memory restoration.