Abstract #3311

Early Marker for Alzheimers Disease: Hippocampus T1ρ (T1ρ ) Estimation

Mohammad Haris¹, Erin McArdle¹, Matthew Sochor¹, Matthew Fenty¹, Anup Singh¹, Christos Davatzikos², John Q. Trojanowski³, Elias R. Melhem, Christopher M. Clark⁴, Ravinder Reddy¹, Arijitt Borthakur¹

¹MMRRCC, Radiology, University of Pennsylvania, Philadephia, PA, USA; ²SBIA, Radiology, University of Pennsylvania, Philadephia, PA, USA; ³Department of Pathology & Lab Medicine, University of Pennsylvania, Philadephia, PA, USA; ⁴Department of Neurology, University of Pennsylvania, Philadephia, PA, USA

For treatment of AD to be most effective, it is believed that the regimen must be started before clinical diagnosis of AD, at the stage of MCI. In the current study, we measured T1rho (T_1ρ) relaxation time in the hippocampus of control, MCI and AD cohorts. The AD individuals showed significantly higher T_1ρ value compared to control and MCI. A significant increased T_1ρ value was also observed in MCI compared to control. We suggest that the measurement of hippocampus T_1ρ relaxation time may provides a marker in the early diagnosis of AD.