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Abstract #3312

T1ρ (T1ρ) MR Imaging in Alzheimer Disease and Parkinsons Disease

Anup Singh1, Mohammad Haris1, Erin McArdle1, Matthew Sochor1, Matthew Fenty1, Christos Davatzikos2, John Q. Trojanowski3, Elias R. Melhem, Christopher M. Clark4, Ravinder Reddy1, Arijitt Borthakur1

1MMRRCC, Radiology, University of Pennsylvania, Philadephia, PA, USA; 2SBIA, Radiology, University of Pennsylvania, Philadephia, PA, USA; 3Department of Pathology & Lab Medicine, University of Pennsylvania, Philadephia, PA, USA; 4Department of Neurology, University of Pennsylvania, Philadephia, PA, USA


Structural neuroimaging has the potential to play an important role in the early diagnosis of both AD and PD. In the current study, we measured the T1rho (T) value in MTL in the brain of control, Parkinson's disease (PD) and Alzheimer's disease (AD). T was significantly increased in AD compared to control and PD. The PD individuals showed decreased T compared to control. We conclude that the serial measurement of T in both AD and PD may provide the nature of disease progression and would contribute to their early diagnosis in the future.