Abstract #3312

T1ρ (T1ρ) MR Imaging in Alzheimer Disease and Parkinsons Disease

Anup Singh¹, Mohammad Haris¹, Erin McArdle¹, Matthew Sochor¹, Matthew Fenty¹, Christos Davatzikos², John Q. Trojanowski³, Elias R. Melhem, Christopher M. Clark⁴, Ravinder Reddy¹, Arijitt Borthakur¹

¹MMRRCC, Radiology, University of Pennsylvania, Philadephia, PA, USA; ²SBIA, Radiology, University of Pennsylvania, Philadephia, PA, USA; ³Department of Pathology & Lab Medicine, University of Pennsylvania, Philadephia, PA, USA; ⁴Department of Neurology, University of Pennsylvania, Philadephia, PA, USA

Structural neuroimaging has the potential to play an important role in the early diagnosis of both AD and PD. In the current study, we measured the T1rho (T_1ρ) value in MTL in the brain of control, Parkinson's disease (PD) and Alzheimer's disease (AD). T_1ρ was significantly increased in AD compared to control and PD. The PD individuals showed decreased T_1ρ compared to control. We conclude that the serial measurement of T_1ρ in both AD and PD may provide the nature of disease progression and would contribute to their early diagnosis in the future.