Yi-Ching Lynn Ho1,2, Amandine Cheze1, Lai-Hong Dennis Cheong1, Esben Thade Petersen1,2, Albert Gjedde2, Kong-Yong Goh3, Yih-Yian Sitoh1, Xavier Golay1
1Neuroradiology, National Neuroscience Institute, Singapore, Singapore; 2Centre For Functionally Integrative Neuroscience, University of Aarhus, Aarhus, Denmark; 3Opthalmology, Tan Tock Seng Hospital, Singapore, Singapore
Visual restitution training (VRT) is a new therapy that apparently facilitates visual field recovery in patients with post-chiasmal infarcts and preserved foveal vision. However, the reasons for the apparent visual field enlargement are unclear, especially in the functional borderzone, where the improvements tend to be seen. In this case study, we aimed to track neurophysiological changes with VRT, using fMRI retinotopic mapping and a paradigm to look at borderzone-related BOLD activity, plus high-resolution DTI to assess white-matter changes. The baseline results of the case study indicate residual neurovascular function around the infarcted zone and may predict therapeutic gains.