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Abstract #3367

Increased Default Mode Activity in Patients with Progressive Supranuclear Palsy

Yu-Chun Lin1, Tien-Min Liu2, Chin-Song Lu3, Yau-Yau Wai1, Jiun-Jie Wang2

1Department of Diagnostic Radiology, ChangGung Memorial Hospital, KweiShan, Taoyuan, Taiwan; 2Department of Medical Imaging and Radiological Science, ChangGung University, Taoyuan, Taiwan; 3Department of Neurology, ChangGung Memorial Hospital, Taoyuan, Taiwan

The present work proposed to examine the changes in the default mode network activity measured during the resting state in patients with PSP. 6 patients with PSP and 6 healthy old controls were acquired on a 3.0 Tesla MR scanner. Subjects were prompted to remain restingly awake without performing any specific task. Data were analyzed through independent component analysis. The results showed increased activations in patients in anterior cingulate and parahipocampus. It might suggest that the neural network in patients of PSP was affected such that increased amount of resources was required to maintain a similar level of performance.