Ling Zou1, Deng Wei2, He-Han Tang3, Li-Jun Jiang2, Wei Yi4, Dong-Ming Li1, Xiu-Li Li5, Fei Li5, Su Lv3, Xiao-qi Huang3, Tao Li2, Qi-Yong Gong1
1Huaxi MR Research Center(HMRRC), West China Hospital, Sichuan Universty, Chengdu, Sichuan, China; 2Psychiatric Center,, West China Hospital, Sichuan Universty, Chengdu, Sichuan, China; 3Huaxi MR Research Center(HMRRC),, West China Hospital, Sichuan Universty, Chengdu, Sichuan, China; 4Radiology, West China Hospital, Sichuan Universty, Chengdu, Sichuan, China; 5Huaxi MR Research Center(HMRRC), , West China Hospital, Sichuan Universty, Chengdu, Sichuan, China
Decreased brain volume was reported as the common finding in schizophrenia patients. Most long-term follow up studies showed the progressive brain volume loss. Our short-term follow up optimized VBM study in antipsychotic-naive schizophrenia patients found the increase volume of left inferior frontal gyrus and right putamen, hippocampus, amygdala. It is possible that patients are sensitive to treatment in short term period, and the effects show as increase of GM volume. However, the meaning of this finding and how it can guide the clinic practices require further clarification. Serial studies are necessary to gain further insight into our findings.
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