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Abstract #3454

Correlation Among in Vivo 1H-MRS Metabolic Profiles, Genetic and Clinical Data in Schizophrenic Patients

Bernardo Celda1,2, Beatriz Martinez-Granados1, MCarmen Martinez-Bisbal2, Olga Brotons3, Eduardo J. Aguilar3, Luis Marti-Bonmati4, Rosa de Frutos5, Olga Rivero5, Julio Sanjuan6

1Physical Chemistry, University of Valencia, Burjassot, Valencia, Spain; 2Physical Chemistry-UVEG, CIBER-BBN, Burjassot, Valencia, Spain; 3Clinic Hospital Valencia, Psychiatry Unit, Valencia, Spain; 4Radiology Unit, Dr. Peset Hospital, Valencia, Spain; 5Genetics, University of Valencia, Burjassot, Valencia, Spain; 6Department of Psychiatry, University of Valencia-CIBERSAM, Valencia, Spain

Auditory hallucinations (AH) are one of the core symptoms in Schizophrenia. A recent model suggests an alteration in language and emotional processing in which the thalamus is largely involved. In vivo thalamus metabolic modifications are larger in schizophrenic patients with AH. Likewise, it has been shown that AH can be related to genetically prone subjects (genes involved in language-FOXP2 gene and 5-HTT gene). In this communication statistical correlations have been found between in vivo metabolic profiles in thalamus and clinical data (PSYRATS) and genetic alterations in the polymorphisms of serotonine transporter gene. These results support thalamus implication in AH pathogenesis.