Abstract #3465

A Multicentre Study of 1H MRS for the Characterisation of Low Grade Brain Tumours of Childhood

Eleni Orphanidou-Vlachou^1,2, Dorothee Auer^3,4, Jonathan Coupland⁴, Nigel P. Davies^2,5, Tim Jaspan⁴, Lesley McPherson², Kal Natarajan^2,5, Dawn Saunders⁶, Yu Sun^1,2, Theodoros Arvanitis^1,2, Richard Grundy^3,4, Andrew Peet^1,2

¹University of Birmingham, Birmingham, UK; ²Birmingham Children's Hospital, Birmingham, UK; ³University of Nottingham, Nottingham, UK; ⁴Nottingham University Hospital, Nottingham, UK; ⁵University Hospital Birmingham, Birmingham, UK; ⁶Great Ormond Street Hospital, London, UK

This is a multicentre study of 1H magnetic resonance spectroscopy for the characterisation of low grade brain tumours of childhood. These tumours are a diverse group and present diagnostic and prognostic challenges to clinicians. Single voxel MRS was performed as part of routine clinical imaging at 3 centres. The results show that MRS has the ability to discriminate between different diagnostic groups and tumours at different brain locations. In addition, it is starting to show evidence of being a valuable non-invasive tool for predicting prognosis. MRS can be performed at multiple centres and the data combined to provide robust results.