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Abstract #3466

Susceptibility Weighted Imaging (SWI) in Children with Brain Stem Glioma During Combined Antiangiogenic and Radiation Therapy.

Jan Sedlacik1, Hoang-Vu Tran1, Ulrike Lbel1, Ralf Lffler1, Jrgen Reichenbach2, Alberto Broniscer1, Zoltan Patay1, Claudia M. Hillenbrand1

1St. Jude Children's Research Hospital, Memphis, TN, USA; 2Friedrich Schiller Universitt, Jena, Germany

Purpose of this study was to monitor the effects of anti-angiogenesis therapy concurrently administered with local irradiation in children with diffuse brainstem glioma by using susceptibility weighted imaging, a method which is sensitive to blood oxygenation and may therefore proof useful as an early marker of tumor response to treatment.