Abstract #3466

Susceptibility Weighted Imaging (SWI) in Children with Brain Stem Glioma During Combined Antiangiogenic and Radiation Therapy.

Jan Sedlacik¹, Hoang-Vu Tran¹, Ulrike Lbel¹, Ralf Lffler¹, Jrgen Reichenbach², Alberto Broniscer¹, Zoltan Patay¹, Claudia M. Hillenbrand¹

¹St. Jude Children's Research Hospital, Memphis, TN, USA; ²Friedrich Schiller Universitt, Jena, Germany

Purpose of this study was to monitor the effects of anti-angiogenesis therapy concurrently administered with local irradiation in children with diffuse brainstem glioma by using susceptibility weighted imaging, a method which is sensitive to blood oxygenation and may therefore proof useful as an early marker of tumor response to treatment.