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Abstract #3480

HR-MAS Spectroscopic Analysis of Biopsies of Thyroid Tumors; a Pilot Study

Poonam Verma1, R K. Singh2, R Ramakant2, Suresh Kumar2, Surendra kumar2, Nuzhat Husain3, Raja Roy1

1CBMR, Centre of Biomedical Magnetic Resonance, Lucknow, Uttar Pradesh, India; 2General surgery, Chhatrapati Shahuji Maharaj Medical University, Lucknow, Uttar Pradesh, India; 3Pathology, Chhatrapati Shahuji Maharaj Medical University, Lucknow, Uttar pradesh, India

Thyroid tissues were subjected to HR-MAS NMR analysis followed by histopathological examination. In malignant cases, the glutamate/alanine, choline/alanine and lactate/alanine ratios were found to be significantly reduced with respective p-values 0.01, 0.02 & 0.007 in the comparison of non-malignant cases. The tissue specimen (n=6) from Hashimoto,s thyroidites showed the presence of additional metabolite,viz. -hydroxybutyrate which was not observed in other thyroid tumor tissue type ,can be used as fingerprint marker. We propose that thyroid tumor tissue metabolic information by NMR has a diagnostic potential along with the gold- standard histopathological examination.