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Abstract #3520

Measuring Small Compartmental Dimensions with Low-Q Angular Double-PGSE NMR

Noam Shemesh1, Evren zarslan2, Peter J. Basser2, Yoram Cohen1

1School of Chemistry, Tel Aviv University, Tel Aviv, Israel; 2Section on Tissue Biophysics and Biomimetics, NICHD, National Institute of Health, Bethesda, MD, USA

In this study, we presented a method employing low amplitude gradients to estimate the pore dimension in restricted compartments, circumventing the need for high q values. We have shown that we can accurately estimate the dimensions of even small pores (5m) when the timing parameters of the low-q angular double-PGSE experiments are incorporated into our simulations, provided that the diffusion times are long enough to probe the boundaries. This experimental study validates the theory that was previously published. Low-q angular d-PGSE NMR may fill an important niche in characterizing compartment sizes in which restricted diffusion occurs.