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Abstract #3538

A Comparative Study Between 4 Optimal DWI Gradient Sampling Schemes: Simulations Based on Constrained Spherical Deconvolution (CSD)

Shiou-Ping Lee1, Jacques-Donald Tournier2, Christopher-P Hess3, Chung-Ming Chen1, Wen-Yih Isaac Tseng4

1Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan; 2Brain Research Institute, Florey Neuroscience Institutes, Austin, Melbourne, Australia; 3Department of Radiology, University of California-San Francisco, San Francisco, California,, USA; 4Center for Optoelectronic Biomedicine, National Taiwan University Medical College, Taipei, Taiwan

The constrained spherical deconvolution (CSD) approach has been shown to be robust to resolve fibers crossing at small angles. Nevertheless, the DW gradient sampling scheme is also crucial to obtain an accurate reconstruction of the fiber orientation distribution (FOD), although the optimal scheme to use with high angular resolution DW imaging (HARDI) methods has not been fully investigated. The goal of this study is to determine the optimal sampling scheme for use with CSD, in terms of the precision of the estimated fiber orientations. This will improve the reliability of performing white matter tractography through crossing fiber regions.