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Abstract #3551

Effects of Coregistration for the Reconstruction of High Angular Resolution Diffusion Imaging

Yi-Ping Chao1, Kun-Hsien Chou2, Kuan-Hung Cho1, Chun-Hung Yeh3, Jyh-Horng Chen1, Ching-Po Lin3,4

1Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan; 2Institute of Biomedical Engineering, National Yang-Ming University, Taipei, Taiwan; 3Institute of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan; 4Institute of Neuroscience, National Yang-Ming University, Taipei, Taiwan

High angular resolution diffusion imaging (HARDI) has been proposed for resolving heterogeneity of white matter fibers within an MR voxel. Long acquisition time of HARDI would lead to image distortion caused by head motion during the scan sessions. Here, we present that initial coregistration step for the high b-value DWIs might be beneficial for the reconstruction of dODFs and subsequent fiber tractography with experimental data. According to the results, it is shown clearly that non-coregistered QBI were influenced more easily by the partial volume effect of adjacent microstructures, especially within the region with tract of single orientation.