Abstract #3551

Effects of Coregistration for the Reconstruction of High Angular Resolution Diffusion Imaging

Yi-Ping Chao¹, Kun-Hsien Chou², Kuan-Hung Cho¹, Chun-Hung Yeh³, Jyh-Horng Chen¹, Ching-Po Lin^3,4

¹Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan; ²Institute of Biomedical Engineering, National Yang-Ming University, Taipei, Taiwan; ³Institute of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan; ⁴Institute of Neuroscience, National Yang-Ming University, Taipei, Taiwan

High angular resolution diffusion imaging (HARDI) has been proposed for resolving heterogeneity of white matter fibers within an MR voxel. Long acquisition time of HARDI would lead to image distortion caused by head motion during the scan sessions. Here, we present that initial coregistration step for the high b-value DWIs might be beneficial for the reconstruction of dODFs and subsequent fiber tractography with experimental data. According to the results, it is shown clearly that non-coregistered QBI were influenced more easily by the partial volume effect of adjacent microstructures, especially within the region with tract of single orientation.