Abstract #3602

Time-Dependent Diffusion MRI in the Neocortex of Aquaporin-4 Deficient and Normal Mice in the Resting State at 7T

Tina Pavlin¹, Christian Brekken¹, Pl Erik Goa², Anna Thoren³, Ole Petter Ottersen³, Erlend A. Nagelhus³, Asta Hberg¹

¹Circulation and Medical Imaging, NTNU, Trondheim, Norway; ²Medical Imaging, St.Olavs Hospital HF, Trondheim, Norway; ³University of Oslo, Oslo, Norway

We use time-dependent diffusion MRI to investigate how complete depletion of aquaporin-4 affects water diffusion in the mice brain. Our measurements show no difference in time-dependent diffusion between knockouts and controls in the resting state. We obtain a bulk diffusion constant of 1x10-5 cm2/s and the tortuosity value of 1.6. Furthermore, the diffusion is monoexponential over the entire range of diffusion times used (from 7 ms to 149 ms) due to the small gradient strengths (and thus q-values) used in these measurements.