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Abstract #3602

Time-Dependent Diffusion MRI in the Neocortex of Aquaporin-4 Deficient and Normal Mice in the Resting State at 7T

Tina Pavlin1, Christian Brekken1, Pl Erik Goa2, Anna Thoren3, Ole Petter Ottersen3, Erlend A. Nagelhus3, Asta Hberg1

1Circulation and Medical Imaging, NTNU, Trondheim, Norway; 2Medical Imaging, St.Olavs Hospital HF, Trondheim, Norway; 3University of Oslo, Oslo, Norway

We use time-dependent diffusion MRI to investigate how complete depletion of aquaporin-4 affects water diffusion in the mice brain. Our measurements show no difference in time-dependent diffusion between knockouts and controls in the resting state. We obtain a bulk diffusion constant of 1x10-5 cm2/s and the tortuosity value of 1.6. Furthermore, the diffusion is monoexponential over the entire range of diffusion times used (from 7 ms to 149 ms) due to the small gradient strengths (and thus q-values) used in these measurements.