Kuan-Hung Cho1, Bing-Hsuan Lei1, Jyh-Horng Chen1
1Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan
Collapsin response mediator protein-1 (CRMP-1) has been identified in brain and implicated in plexin-dependent neuronal function. CRMP-1 knock-out mice exhibited impaired performance in hippocampal-dependent spatial learning and memory tests, and disorganized MAP2 staining in the distal dendrites of hippocampal CA1 pyramidal cells. In this study we use diffusion tensor imaging (DTI) to noninvasively and quantitatively investigate the change of diffusion properties of the knock-out of the CRMP-1.