Abstract #3607

Absolute Cerebral Volume Quantification by Vascular Space Occupancy Technique on Rat Model with Optimized Inversion Time

Chien-Chung Chen¹, Yi-Chun Wu¹, Chou-Ming Cheng², Tzu-Chen Yeh³, Fu-Nien Wang¹

¹Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan; ²Integrated Brain Research Laboratory, Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan; ³Integrated Brain Research Laboratory, Department of Medical Research and Education, Taipei Veterans General Hospital, Taiwan

A TI optimization method for vascular space occupancy (VASO) technique was implemented to quantification the absolute cerebral blood volume (CBV) on a rat model. The information of relative CBV from dynamic susceptibility contrast (DSC) imaging is included to find the optimized TI which maximize the R square between relative CBV from DSC method and absolute CBV from VASO method. It is also noted that when using VASO technique with a TI apart from the optimized one, the R square is significantly reduced between DSC and VASO methods, which could reduce the accuracy of absolute CBV measurement.