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Abstract #3611

Dynamic Contrast Enhanced MRI Parameters Independent of Baseline T1 Values

Junyu Guo1, Wilburn E. Reddick1

1Radiological Sciences, St. Jude Children's Research Hospital, memphis, TN, USA

In this abstract, we systematically investigate the baseline T1 independence of the commonly used DCE-MRI kinetic parameters (Ktrans, kep, ve and IAUC) and the new-defined parameters (the normalized ratios (NR) of the corresponding kinetic parameters) for a gradient-echo pulse sequence using simulations and in vivo studies. We found that DCE-MRI parameters, kep and its NR, are approximately independent of the baseline T1 and the T1 difference between pre- and post-treatment. The other kinetic parameters and their NRs have to be carefully used when the baseline T1 measurement is not available or not accurate.