Junyu Guo1, Wilburn E. Reddick1
1Radiological Sciences, St. Jude Children's Research Hospital, memphis, TN, USA
In this abstract, we systematically investigate the baseline T1 independence of the commonly used DCE-MRI kinetic parameters (Ktrans, kep, ve and IAUC) and the new-defined parameters (the normalized ratios (NR) of the corresponding kinetic parameters) for a gradient-echo pulse sequence using simulations and in vivo studies. We found that DCE-MRI parameters, kep and its NR, are approximately independent of the baseline T1 and the T1 difference between pre- and post-treatment. The other kinetic parameters and their NRs have to be carefully used when the baseline T1 measurement is not available or not accurate.
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