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Abstract #3618

SCALE PWI: A Pulse Sequence for Quantitative Cerebral Perfusion Imaging

Jessy J. Mouannes1, Saurabh Shah2, Wanyong Shin3, Octavia Biris1, Timothy J. Carroll1,4

1Biomedical Engineering, Northwestern University, Chicago, IL, USA; 2Siemens Medical Solutions USA, Inc, Chicago, IL, USA; 3National Institute on Drug Abuse, National Institute of Health, Baltimore, MD, USA; 4Radiology, Northwestern University, Chicago, IL, USA

CALibrated Epi Perfusion Weighted Imaging (SCALE-PWI) is a new sequence that produces an absolute scale for the quantification of cerebral perfusion. This sequence implements the Bookend technique, a reproducible and reliable MRI method for quantitative cerebral perfusion, in a single push-button scan. This eliminates the need for multiple Bookend scans which requires special technologist training, is less prone to motion artifacts, and, ultimately, produces quantitative images of cerebral perfusion without the need for offline post-processing. A validation of this sequence is presented for 19 healthy subjects at 1.5 T.