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Abstract #3621

Unique Thalamic Perfusion Abnormalities in Painful But Not Painless Diabetic Peripheral Neuropathy.

Dinesh Selvarajah1, Celia Emery2, Rajiv Gandhi2, Paul Griffiths1, Solomon Tesfaye2, Iain Wilkinson1

1Academic Department of Radiology, University of Sheffield, Sheffield, UK; 2Diabetes Research Department, University of Sheffield, Sheffield, UK

Painful diabetic neuropathy is a common complication of diabetes with serious consequences. Its pathogenesis, however, remains unknown. Using a new technique to analyze dynamic contrast enhanced MR perfusion imaging, we demonstrate unique thalamic microvascular abnormalities in painful but not painless neuropathy. This may provide important clues to the pathogenesis of pain in diabetes.